Guanfacine
Alpha-2A agonist ADHD non-stimulant
Episodes
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#4100: Can ADHD Drugs Be Heart-Safe?Stimulants work for ADHD but strain the heart. Can we separate the benefits from the risks? -
#3519: ADHD, Depression, and the Red Pill Blue Pill MomentCan you treat ADHD first and then stop antidepressants? A deep dive into secondary depression, tapering, and long-term treatment. -
#3518: What Irritability Actually Is (And Why It Feels Like Your Nerves Are At You)Irritability isn't anger without a press release. Here's what's happening in your brain when everything feels like an intrusion. -
#3268: Why Strattera Works (or Fails) Depending on Your LiverHow one liver enzyme explains wildly different reactions to the same ADHD drug. -
#3248: Why Isn't Modafinil Used More for ADHD?Modafinil boosts wakefulness and dopamine. So why does it lose to stimulants for ADHD? -
#843: The Mechanistic Phase: Why Long COVID Finally Has AnswersWhile the world moves on, 65 million people remain in the shadow pandemic. Explore the latest 2026 breakthroughs in Long COVID science. -
#839: Beyond Stimulants: Fine-Tuning the ADHD BrainDiscover how blood pressure meds like Guanfacine are revolutionizing ADHD treatment by "plugging the leaks" in the prefrontal cortex. -
#838: The Afternoon Crash: ADHD Boosters and MetabolismWhy do ADHD meds wear off early? Explore the science of fast metabolism and the role of booster doses in managing the daily neurochemical curve. -
#834: The Chemistry of Focus: Dopamine, ADHD, and the BrainWhy do ADHD meds work for some but not others? Explore the delicate balance of dopamine, norepinephrine, and the brain's internal wiring.