#addiction-treatment
7 episodes
#3260: How 10,000 Lever Presses Predict Addiction Risk
How rat breakpoints predict human abuse potential — and whether we can replace animal testing.
#3253: Nicotine Receptors & Bupropion: How an Antidepressant Blocks Smoking
How bupropion hijacks nicotinic receptors to cut smoking reward and withdrawal — and why these receptors aren't really "nicotine" receptors.
#2533: Can Ibogaine Really Reset Addiction?
A deep dive into ibogaine's anti-addictive potential, cardiac risks, and the push for FDA-approved analogs.
#2321: Kratom’s Double-Edged Leaf: Science vs. Marketing
From ancient remedy to modern supplement, Kratom’s story reveals gaps between marketing, science, and global regulation.
#445: Beyond the Pill: The Science of Tapering Sleep Meds
Herman and Corn explore the science of tapering sleep meds, the "histamine rebound," and how to reclaim your natural rest.
#395: Brain on Fire: The Science of the Kindling Effect
Why does alcohol withdrawal get more dangerous every time? Explore the "kindling effect" and how the brain learns to become hyper-excitable.
#356: Beyond the Bottle: The New Science of Alcohol Use Disorder
Explore how 20 years of medical progress transformed our understanding of addiction from a moral failing to a biological reality.